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What Is Ozempic?
Both Ozempic and Wegovy are brand names of Semaglutide. This is a long-acting GLP-1 reception agonist, which can get administered subcutaneously once weekly.
It has been shown effective in weight loss in trials involving patients with or without Type 2 Diabetes. In fact, Ozempic was actually developed to treat Type 2 Diabetes, as it helps lower blood glucose levels.
But it ended up having a side benefit of weight loss which was then perpetuated as folks without Type 2 Diabetes started ordering Ozempic to help lose weight.
Keep in mind that only the injectable form, Wegovy, is approved for the treatment of obesity (not the oral version).
Semglutide has also been shown to reduce cardiovascular (CV) risk factors in patients with established CV disorders in some CV outcome trials.
How Does Ozempic Work for Weight Loss?
Once considered overweight or obese, the treatment goes as follows: Ozempic injections at the maximum dose (2.4 mg weekly) help achieve maximum weight loss.
But patients shouldn’t start with the maximum dose right away, as some can’t tolerate the dose and might have side effects, like nausea, or vomiting. That’s why a gradual increase in the dose is recommended.
How Semaglutide (Ozempic and Wegovy) works for weight loss is quite interesting. GLP-1 is a major incretin hormone in humans. That is, it increases insulin section, inhibits glucagon release, and suppresses hepatic gluconeogenesis.
Semaglutide also causes delayed gastric emptying, reduced appetite, and energy intake, which is why it has beneficial effects on weight loss. It reduces the rate at which your stomach empties food after a meal (gastric emptying). The longer time it takes for gastric emptying, the more time food stays in your stomach, making you feel fuller longer.
This results in reduced hunger, and appetite. Overall, patients on Ozempic or Wegovy end up eating less food and thus losing weight.
Not only does Ozempic affect gastric emptying, but it also affects GLP-1 receptors found in the hypothalamus which are responsible for regulating food intake in the nervous system. This reduces feelings of hunger and appetite in obese individuals.
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Furthermore, GLP-1 also affects those receptors responsible for satiety in the brain. It stimulates these specific neurons thus increasing satiety in patients who were administered Ozempic. Now that you know what is Ozempic used for, let’s look further into dosage and other intake instructions.
Where Do I Inject Ozempic?
A study showed that taking Ozempic in a fasting state has the most optimal effect on achieving therapeutic concentration. Fasting for another half an hour after the dose intake is beneficial.
Additionally, Ozempic must get administered under the skin, in the subcutaneous or fatty layer, on your lower abdomen (near the waist), front of the thighs, or upper arm. Do not inject Ozempic into a muscle or vein.
Make sure to rotate (change) your injection site with each injection. Do not use the same injection site with each injection, or if you do choose the same site, do not use the same location each time.
Dose titration is necessary with Ozempic. That is, patients should start therapy with 0.25 mg, then raise it to 0.5 mg, and then to 1 mg, keeping 4 weeks interval. Ozempic pen (red and blue) is available in a strength of 1.34 mg/ml.
The red pen delivers a 0.25 mg initiation dose and 0.5 mg for maintenance purposes. On the other hand, the blue pen is meant for 1.0 mg (maximum maintenance dose) of Semaglutide.
Which Foods Should I Avoid While on Ozempic?
When patients first start taking Ozempic, some side effects like diarrhea, nausea, or vomiting can ensue. But these may disappear over time as the patient gets used to the medication.
To help the body adjust to the medication and dosing, avoiding fried foods and fatty foods, such as fast food, and foods high in sugar is recommended. Ozempic and fatty foods are not friends – they can exacerbate the side effects.
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